The objective of the present work was to study the antidiabetic effect of aqueous extract of Murraya koenigii stem bark against alloxan induced diabetes in rats. The diabetes was induced by single dose of alloxan (150 mg/kg, i.p.). 03 days after induction of diabetes, the diabetic animals were treated further for 11 days with aqueous extract of Murraya koenigii stem bark (125 mg/kg and 250 mg/kg) and metformin (50 mg/kg). Blood glucose estimation was performed on 0, 4, 7 and 10th day. At the end of study period, animals were sacrificed for biochemical investigations. Alloxan induced diabetic rats showed marked hyperglycemia at the end of study period. Body weight and liver glycogen levels were significantly reduced in diabetic rats. Posttreatment with aqueous extract of Murraya koenigii stem bark for 11 days (125 mg/kg and 250 mg/kg) significantly ameliorated the alterations in fasting blood glucose, serum triglyceride, serum cholesterol, liver glycogen levels as well as body weight in diabetic rats. Thus, present study suggested the potential antidiabetic activity of aqueous extract of Murraya koenigii stem bark against diabetes mellitus.
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